Tail-flick

The tail-flick test is a classic nociceptive test originally described by D’Amour and Smith (1941), and modified by Dewey et al. (1970) using a Columbus Tail-Flick Analgesia Meter. Since then, this test has become standard,efficient and very predictive analgesic development method.

Because of the nature of assessment and severity, this test is the most suitable assay for CNS and potent analgesics,such as opioid agonists and potency-similar compounds. Some Muscranic and nicotinic agonists also show good analgesic activity in this test.

By using IITC rodent tail-flick analgesic meter, we have established and validated this assay with rats and mice in our lab, and it is available for screening suitable compounds of potent analgesic drug candidates.